If you're driving to Glasgow from England and the south of Scotland, you'll probably approach the city via the M6, M74, and A74. The City Centre is clearly marked from these roads. From Edinburgh, the M8 leads to the City Centre. From the north, the A82 from Fort William and the A82/M80 from Stirling join the M8 in the City Centre.
You don't need a car in Glasgow, and you're probably better off without one. Although most modern hotels have their own lots, parking can be trying. In the City Centre meters are expensive, running about £2.40 per hour during the day. In the West End they cost 80 pence per hour, but you often have to feed the meter until 10 pm. Don't even consider parking illegally, as fines are upward of £30. Multistory garages are open 24 hours a day at Anderston Centre, George Street, Waterloo Place, Mitchell Street, Cambridge Street, and Concert Square. Rates run between £1 and £2 per hour. More convenient are the park-and-ride operations at some subway stations (Kelvinbridge, Bridge Street, and Shields Road).